China Fibrinolysis Inhibitng Factor CAS NO.67869-62-9 manufacturers and suppliers

Fibrinolysis Inhibitng Factor CAS NO.67869-62-9

Short Description:

Fibrinolysis Inhibiting Factor (GPRP Tetrapeptide)

Fibrinolysis Inhibiting Factor (commonly referred to as GPRP tetrapeptide, H-Gly-Pro-Arg-Pro-OH) is a synthetic research-grade peptide that mimics the N-terminal “knob” region of the fibrin α-chain, supplied as a white to off-white lyophilized powder with ≥95% purity by RP-HPLC.

Research Application

It is specifically designed for coagulation biology and hemostasis research, functioning as a classical tool to modulate fibrin polymerization and protect fibrinogen-fibrin complexes from plasmin degradation in controlled in vitro experimental systems.

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Technical Specifications

Item	Specification
Product Name	Fibrinolysis Inhibitng Factor
CAS NO.	67869-62-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C18H31N7O5
Molecular Weight	425.49 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Freely soluble in distilled water (≥ 50 mg/mL); also soluble in DMSO or dilute acetic acid; reconstitute to desired concentration in buffer or cell-free system as needed
Endotoxin	≤0.001 EU/mg
Biological Activity	Binds to the “a” polymerization pocket (D-domain hole) of fibrinogen/fibrin with higher affinity than native fibrin α-chain knob; blocks fibrin monomer “knob-hole” assembly, inhibits fibrin polymerization and Factor XIIIa-mediated crosslinking; GPRP–fibrinogen complex shows increased resistance to plasmin degradation
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1. MECHANISM OF ACTION

This peptide competitively binds to the “a” polymerization pocket (D-domain hole) within the β- and γ-chains of fibrinogen/fibrin with higher affinity than the native fibrin α-chain knob, thereby occupying the polymerization site and sterically blocking the normal “knob-hole” interaction required for fibrin monomer assembly. By forming a stable GPRP–fibrinogen complex, it prevents further fibrin fiber formation and inhibits Factor XIIIa-mediated crosslinking of fibrin chains, while the resulting complex exhibits increased resistance to plasmin-induced proteolysis, making it a valuable modulator of the fibrinolytic cascade in mechanistic studies.

Fibrinolysis Inhibitng Factor CAS NO.67869-62-9

2. PRODUCT INDICATIONS

* For Research Use Only, Not for Human or Veterinary Diagnostic/Therapeutic Use.

This product is intended exclusively for laboratory research use and is suitable for universities, hospitals, and biopharmaceutical R&D laboratories investigating hemostasis, thrombosis mechanisms, and fibrinolytic pathway regulation. Typical applications include fibrin polymerization inhibition assays, thromboelastography (TEG) calibration controls, preparation of thrombin-degranulated platelet suspensions (to prevent fibrin entrapment), and as a positive control in coagulation factor XIIIa activity or plasmin resistance studies using purified proteins or citrated human plasma.

3. CLINICAL EFFICACY OF PRODUCT

Although this peptide is not a drug and has no approved clinical application, published preclinical and ex vivo studies demonstrate that GPRP effectively inhibits fibrin clot formation and alters thromboelastographic parameters toward a hypocoagulative state in human plasma models, and its ability to block fibrin assembly has been extensively validated as a benchmark for understanding physiologic fibrin stabilization and pathologic hyperfibrinolysis. The term “efficacy” here refers strictly to its proven utility in reproducing and interrupting fibrin polymerization in validated research models, supporting the development of next-generation antifibrinolytic therapeutics and coagulation diagnostic assays.

4. Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

✓ 1. A rigorous quality management system
✓ 2. Batch traceability and stability data
✓ 3. Professional laboratory testing and validation
✓ 4. Compliance with international trade standards

Our production partners all employ GMP-compliant production systems. Each batch comes with COA, HPLC purity report, and MS chromatograms.

5. DELIVERY & SHIPPING

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation. Custom packaging available upon request.

Shipping Methods

Main Method: International Air Freight (DHL, FedEx, UPS, TNT). Ensures the fastest transit time and minimizes environmental impact.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry.

Hot Tags: Fibrinolysis Inhibiting Factor, GPRP Peptide, Gly-Pro-Arg-Pro, Fibrin Polymerization Inhibitor, Coagulation Research Peptide, Factor XIIIa Inhibitor, Hemostasis Assay Reagent, Thrombosis Research, Fibrinolysis Study Tool, Research Use Only Peptide.

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Besides, you can contact us if you have any other questions

Q1: Can i get some samples?

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments?

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Unionor Paypal or Escrow(Alibaba).

Q3: How to confirm the Product Quality before placing orders?

A:You can get free samples for some products,you only need to pay the shipping costor arrange a courier to us and take the samples. You can send us your product specifi-cations and requests,we will manufacture the products according to your requests.

Q4:What’s your MOQ?

A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the conditionthat sample charge is 100% paid.

Q5: How about delivery lead time?

A: Delivery lead time: About 1-3 days after payment confirmed. (Chinese holiday notincluded)

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