Bombesin CAS NO.31362-50-2

1. MECHANISM OF ACTION

This peptide exerts its effects by selectively binding to and activating G protein-coupled receptors, primarily the Gastrin-Releasing Peptide Receptor (GRPR/BB2) and Neuromedin B Receptor (NMBR/BB1). This interaction triggers Gq/11-mediated phospholipase C (PLC) activation, leading to the generation of inositol triphosphate (IP3) and diacylglycerol (DAG), which subsequently mobilize intracellular calcium stores and activate downstream signaling cascades such as PKC and MAPK/ERK pathways, thereby regulating smooth muscle contraction, hormone secretion, and mitogenic responses.

2. PRODUCT INDICATIONS

This product is strictly intended for scientific research use only (RUO) and is widely utilized by academic institutions and biopharmaceutical R&D departments. It is indicated for studies involving GRPR/NMBR functional characterization, investigation of gut-brain axis signaling, and stimulation assays in SCLC or prostate cancer cell lines overexpressing GRPR. Additionally, it functions as a validated starting material for the synthesis of radiolabeled analogs used in preclinical tumor imaging and targeted radiotherapy models.

3. CLINICAL EFFICACY OF PRODUCT

While not an approved therapeutic for human use, preclinical efficacy studies utilizing Bombesin-based probes have demonstrated significant potential in clinical translation research. Radiolabeled derivatives (e.g., ⁶⁸Ga-Bombesin) exhibit high-specificity uptake in GRPR-positive xenografts, providing clear visualization in PET/SPECT imaging for prostate and breast cancer detection. Furthermore, therapeutic analogs show promising dose-dependent tumor growth inhibition in animal models, validating the peptide’s utility as a molecular scaffold for precision medicine development.

4. Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5. DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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