China Influenza HA (110 – 119) CAS NO.132031-50-6 manufacturers and suppliers

Influenza HA (110 – 119) CAS NO.132031-50-6

Short Description:

Influenza HA (110-119)

Influenza HA (110-119) is a synthetic decapeptide corresponding to residues 110 through 119 (Sequence: SFERFEIFPK) of the Influenza A virus Hemagglutinin (HA) protein, supplied as a high-purity white lyophilized powder strictly for non-clinical immunological and virological research.

Characterization

It is characterized as a H-2I-Ed-restricted CD4+ T-cell epitope that plays a distinct role in modulating immune responses, specifically serving as a critical reagent for scientists studying antigen presentation, T-regulatory (Treg) cell biology, and the humoral immunity against influenza.

Intended Use

This product is specifically designed for use by immunologists, vaccine researchers, and diagnostic developers who require a reliable positive control to stimulate HA-specific T-cells, measure immune suppression or activation in assay systems, and evaluate the processing of viral envelope proteins in antigen-presenting cells.

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Technical Specifications

Item	Specification
Product Name	Influenza HA (110 – 119)
CAS NO.	132031-50-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C63H90N14O16
Molecular Weight	1299.5 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Soluble in water or dilute acetic acid; insoluble in common organic solvents
Endotoxin	≤0.5 EU/mg
Biological Activity	Binds stably to H-2I-Ed molecules, induces robust CD4+ T-cell proliferation, and serves as an immune modulatory epitope for studying influenza immunity and vaccine efficacy
Storage Conditions	Store at -20°C in a dry, dark, and well-sealed container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1kit

1. MECHANISM OF ACTION

The biological function of Influenza HA (110-119) is defined by its specific interaction with the Major Histocompatibility Complex class II (MHC II) molecule, particularly the H-2I-Ed allele, forming a peptide-MHC complex that is recognized by the T-cell receptor (TCR) on CD4+ helper T-cells. Unlike internal viral proteins that typically trigger MHC I restricted cytotoxic responses, this extracellular HA-derived fragment is processed and presented on the surface of antigen-presenting cells (APCs) like dendritic cells to engage the CD4+ T-cell compartment. Notably, this specific epitope possesses the unique capacity to selectively stimulate the proliferation and activation of CD4+ CD25+ Regulatory T cells (Tregs), which in turn exert suppressive functions on effector T-cell responses, thereby influencing the fine-tuning of the overall immune balance and preventing excessive immunopathology during viral encounters.

Influenza HA (110 – 119) CAS NO.132031-50-6

2. PRODUCT INDICATIONS

This product is indicated for preclinical research applications targeting professionals in viral immunology, autoimmune research, and vaccine technology who are investigating the nuances of CD4+ T-cell epitope mapping and immune regulation. It is particularly suitable for researchers utilizing the peptide to pulse bone marrow-derived dendritic cells or splenocytes to study antigen presentation dynamics, to isolate and expand influenza-specific T-cell lines, or to model immune tolerance mechanisms in vitro. Furthermore, it is applicable for scientists conducting structure-activity relationship studies on HA epitopes, serving as a standard for ELISA coating to detect HA-specific antibodies, and for pharmacologists testing immunomodulatory drugs that aim to manipulate Treg function or Th cell differentiation, all within controlled laboratory environments.

3. CLINICAL EFFICACY OF PRODUCT

As a raw synthetic peptide reagent not formulated for human therapeutic or diagnostic administration, Influenza HA (110-119) does not possess approved clinical efficacy, yet it is fundamental in elucidating immune correlates validated in extensive preclinical and clinical immunological studies. Experimental data confirm that HA-specific CD4+ T-cells recognize this epitope across different influenza strains, and that analogs of this peptide can enhance T-cell activation by modifying dendritic cell antigen presentation functions or activate Treg suppressor mechanisms. Additionally, research highlights its utility in dissecting why certain HA epitopes induce tolerance versus immunity, underscing its value as a benchmark tool for measuring CD4+ T-cell memory, designing adjuvanted vaccines that optimize T-helper responses, and developing peptide-based immunotherapies for autoimmune conditions rather than acting as a standalone clinical treatment.

4. Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications. Our production partners all employ GMP-compliant production systems and possess standardized quality control processes.

[✓] A rigorous quality management system
[✓] Batch traceability and stability data
[✓] Professional laboratory testing and validation
[✓] Compliance with international trade standards

5. DELIVERY & SHIPPING

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation. We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight. We primarily use DHL, FedEx, UPS, and TNT because of their global reliability and speed.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry.

Hot Tags: T-cell Epitope, Synthetic Peptide, Hemagglutinin, Influenza A, Immunology, Vaccine Research, Treg, MHC Class II, SFERFEIFPK, Immune Regulation, Antigen Presentation, CD4+ T-cell.

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Besides, you can contact us if you have any other questions

Q1: Can i get some samples?

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments?

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Unionor Paypal or Escrow(Alibaba).

Q3: How to confirm the Product Quality before placing orders?

A:You can get free samples for some products,you only need to pay the shipping costor arrange a courier to us and take the samples. You can send us your product specifi-cations and requests,we will manufacture the products according to your requests.

Q4:What’s your MOQ?

A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the conditionthat sample charge is 100% paid.

Q5: How about delivery lead time?

A: Delivery lead time: About 1-3 days after payment confirmed. (Chinese holiday notincluded)

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